Kuchuluka kwa ma buffers kumafunika pakuyeretsa kutsika kwa ma biopharmaceuticals. Kulondola komanso kupangika kwa ma buffers kumakhudza kwambiri njira yoyeretsera mapuloteni. Njira yochepetsera pa intaneti komanso pa intaneti ya dosing imatha kuphatikiza ma buffer amtundu umodzi. Mowa wamayi ndi zosakaniza zimasakanizidwa pa intaneti kuti mupeze yankho lomwe mukufuna. Zogulitsazo zimachokera ku chidziwitso cha sayansi, ndipo khalidweli limachokera ku lingaliro la mapangidwe (QbD). Kupyolera mu nthawi yeniyeni pa intaneti (Real in time) kuyang'anira ndi kulamulira zizindikiro ziwiri za mankhwala, makhalidwe ofunika kwambiri (CQA) a mankhwala (CQA), pH ndi conductivity panthawi yopanga, Onetsetsani kuti mukupereka ma buffers okhazikika komanso yunifolomu. njira zotsikira pansi kuti zithandizire makampani a biopharmaceutical' parameter kutulutsa zolinga. Kukonzekera kwamwambo wamadzimadzi kumafunikira matanki ambiri komanso voliyumu yayikulu. IVEN ikubweretsa makasitomala chidziwitso chatsopano chaukadaulo, kuchepetsa kutsika kwa dosing wa buffer poyeretsa, ndikuchepetsa ndalama zogulira zisanachitike ndi zopanga pambuyo popanga ndi ntchito. , Kupititsa patsogolo luso la kupanga, kuonetsetsa kuti zofunikira za ndondomeko (CPP) za buffer ndi traceability yake, ndipo potsirizira pake kusintha khalidwe la mankhwala.