Pankhani yamapaketi azachipatala, mabotolo a polypropylene (PP) akhala njira yayikulu yopangira mayankho a intravenous infusion (IV) chifukwa cha kukhazikika kwawo kwamankhwala, kukana kutentha kwambiri, komanso chitetezo chachilengedwe. Ndi kukula kwa kufunikira kwachipatala padziko lonse lapansi komanso kukwezedwa kwa miyezo yamakampani opanga mankhwala, mizere yopangira mayankho a PP botolo IV pang'onopang'ono ikukhala muyeso pamsika. Nkhaniyi ifotokoza mwadongosolo zida zoyambira, zabwino zaukadaulo, komanso chiyembekezo chamsika chamzere wopangira PP botolo IV.

Zida zazikulu za mzere wopanga: kuphatikiza modular ndi mgwirizano wolondola kwambiri

ZamakonoPP botolo IV njira kupanga njiraimakhala ndi zida zitatu zazikulu: makina ojambulira preform/hanger, makina omangira, ndi kuyeretsa, kudzaza, ndi makina osindikizira. Njira yonseyi imalumikizidwa mosadukiza kudzera mudongosolo lanzeru lowongolera.

1. Pre kuumba / hanger jekeseni makina: kuyala maziko mwatsatanetsatane akamaumba luso

Monga poyambira mzere wopangira, makina omangira opangira makina amatengera ukadaulo wa jakisoni wothamanga kwambiri kuti asungunuke ndikusintha tinthu tating'ono ta PP pa kutentha kwakukulu kwa 180-220 ℃, ndikuwabaya m'mabotolo osowekapo kudzera mu nkhungu zolondola kwambiri. Mbadwo watsopano wa zida uli ndi makina oyendetsa galimoto a servo, omwe amatha kufupikitsa kuzungulira kwa masekondi 6-8 ndikuwongolera cholakwika cholemetsa cha botolo chopanda kanthu mkati mwa ± 0.1g. Kapangidwe ka kalembedwe ka hanger kumatha kumaliza kuumba kwa mphete yonyamulira pakamwa pa botolo, kulumikizana mwachindunji ndi kuwomba kotsatira, kupewa chiwopsezo cha kuipitsidwa kwachiwiri pazachikhalidwe.

2. Makina owombera botolo amadzimadzi okha: ogwira mtima, opulumutsa mphamvu komanso chitsimikizo cha khalidwe

Makina owuzira botolo amatengera ukadaulo wowombeza wotambasula imodzi (ISBM). Pansi pa biaxial directional kutambasula, botolo lopanda kanthu limatenthedwa, limatambasulidwa, ndikuwumbidwa mkati mwa masekondi 10-12. Zipangizozi zili ndi makina owongolera kutentha kwa infrared kuti zitsimikizire kuti cholakwika cha makulidwe a botolo ndi ochepera 5%, ndipo kuthamanga kophulika kuli pamwamba pa 1.2MPa. Kupyolera muukadaulo wowongolera kutsekeka kwamphamvu, kugwiritsa ntchito mphamvu kumachepetsedwa ndi 30% poyerekeza ndi zida zachikhalidwe, ndikukwaniritsa kutulutsa kokhazikika kwa mabotolo 2000-2500 pa ola limodzi.

3. Atatu mu imodzi yoyeretsa, kudzaza ndi kusindikiza makina: maziko a aseptic kupanga

Chipangizochi chimaphatikiza zigawo zazikulu zitatu zogwira ntchito: kuyeretsa kwa akupanga, kudzaza mochulukira, ndi kusindikiza kotentha kosungunuka.

Chigawo choyeretsera: Kutengera njira yosinthira madzi osmosis yamitundu yambiri, kuphatikiza kusefera kwa 0.22 μ m terminal, kuonetsetsa kuti madzi oyeretsera amakumana ndi pharmacopoeia WFI muyezo.

Chigawo chodzaza: chokhala ndi mita yoyenda bwino komanso mawonekedwe owoneka bwino, ndikudzaza kulondola kwa ± 1ml ndi liwiro lodzaza mpaka mabotolo 120 / mphindi.

Chisindikizo chosindikizira: pogwiritsa ntchito laser kuzindikira ndi ukadaulo wosindikizira mpweya wotentha, chiwopsezo chosindikiza chimaposa 99.9%, ndipo mphamvu yosindikiza ndi yayikulu kuposa 15N/mm².

Ubwino waukadaulo wamtundu wonse: zotsogola muluntha komanso kukhazikika

1. Dongosolo lathunthu lopanda chitsimikizo

Mzerewu umapangidwa ndi kuwongolera chilengedwe chachipinda choyera (ISO level 8), kudzipatula kwa laminar flow hood, ndi zida zapa electrolytic polishing, kuphatikiza ndi CIP/SIP pa intaneti kuyeretsa ndi njira yolera yotseketsa, kuti ikwaniritse zofunikira zaukhondo za GMP A-level ndikuchepetsa chiopsezo choipitsidwa ndi tizilombo topitilira 90%.

2. Kuwongolera mwanzeru

Okonzeka ndi dongosolo MES kupanga kuphedwa, kuwunika zenizeni nthawi ya zida OEE (mwanthaka zida Mwachangu), ndondomeko chizindikiro kupatuka chenjezo, ndi kukhathamiritsa kupanga liwiro kudzera kusanthula lalikulu deta. Kuchuluka kwa makina a mzere wonsewo kwafika pa 95%, ndipo chiwerengero cha malo olowera pamanja chachepetsedwa kufika pa 3.

3. Kusintha kwa kupanga zobiriwira

Kubwezeretsanso kwa 100% kwa zinthu za PP kumagwirizana ndi zochitika zachilengedwe. Mzere wopangira umachepetsa kugwiritsa ntchito mphamvu ndi 15% kudzera pazida zobwezeretsa kutentha kwa zinyalala, ndipo njira yobwezeretsanso zinyalala imawonjezera kuchuluka kwa zotsalira mpaka 80%. Poyerekeza ndi mabotolo agalasi, kuwonongeka kwa kayendedwe ka mabotolo a PP kwatsika kuchoka pa 2% mpaka 0.1%, ndipo mpweya wa carbon wachepetsedwa ndi 40%.

Chiyembekezo chamsika: kukula kwapawiri komwe kumayendetsedwa ndi kufunikira komanso ukadaulo waukadaulo

1. Mwayi wakukulitsa msika wapadziko lonse lapansi

Malinga ndi Grand View Research, msika wapadziko lonse lapansi wothira m'mitsempha ukuyembekezeka kukula pamlingo wokulirapo pachaka wa 6.2% kuyambira 2023 mpaka 2030, ndi kukula kwa msika wa botolo la PP kupitilira $4.7 biliyoni pofika 2023.

2. Malangizo okweza luso

Kupanga kosinthika: Pangani njira yosinthira nkhungu mwachangu kuti mukwaniritse nthawi yosakwana mphindi 30 pamitundu yamabotolo amitundu yambiri kuchokera 125ml mpaka 1000ml.
Kukweza kwa digito: Kuyambitsa ukadaulo wamapasa a digito pakuwongolera zolakwika, kuchepetsa kuzungulira kwa zida ndi 20%.

Kupanga zinthu zatsopano: Pangani zida za copolymer PP zomwe zimalimbana ndi kutsekereza kwa gamma ray ndikukulitsa ntchito zawo mu biologics.

Themakina opangira okha a PP botolo IV yankhoikusinthanso mawonekedwe amakampani opanga ma intravenous intravenous intravenous intravenous intravenous design modular, control intelligent, and green production technology. Ndi kufunikira kwa homogenization yazachipatala padziko lonse lapansi, mzere wopangira uwu womwe umagwirizanitsa bwino, chitetezo, ndi chitetezo cha chilengedwe upitiliza kupanga phindu pamakampaniwo ndikukhala njira yoyeserera pakukweza zida zamankhwala.